"Nobel Prize in Chemistry – Ubiquitin, Deciding the Fate of Defective Proteins in Living Cells"International Awards
Distinguished Prof. Avram Hershko and Distinguished Prof. Aaron Ciechanover
Technion – Israel Institute of Technology
Protein degradation is a critical process in cellular health, and understanding this process improves our knowledge in multiple fields ranging from neuroscience to development of anti-cancer therapies.The scientists revealed how defective proteins are destroyed by tagging them with ubiquitin, which leads to their destruction by a “cellular shredder”. For the unveiling of the ubiquitin system, Prof. Hershko and Prof. Ciechanover won the Nobel Prize in Chemistry in 2004, the first for Israeli scientists.